West syndrome is an age-specific epileptic encephalopathy characterized by epileptic spasms that occur in clusters, a hypsarrhythmic electroencephalographic (EEG) pattern, and developmental delay. The resolution of hypsarrhythmia and cessation of spasms are the principal goals of effective treatment [1–3]. Administration of vigabatrin, adrenocorticotrophic hormone (ACTH), and corticosteroids, alone or in combination, remains the standard therapy for West syndrome [4–7]. This “all-or-none” treatment endpoint was believed to be associated with the best cognitive and neurodevelopmental outcomes, including reduced evolution to other seizure disorders [8].
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