Voltage-gated potassium (K+) channels of the Kv3 family are believed to facilitate high-frequency (>500 Hz) firing of action potentials (APs). The Kv3 channels have unique biophysical properties, including high thresholds of channel activation, rapid activation/deactivation kinetics, and relatively large conductance[1–5]. To date, four Kv3 genes have been identified in the mammalian brain: KCNC1, KCNC2, KCNC3, and KCNC4. They alternatively produce different splice variants that generate multiple channel-protein isoforms (Kv3.1, Kv3.2, Kv3.3, and Kv3.4)[6, 7].
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