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Infantile epileptic spasms syndrome (IESS), characterized by epileptic spasms, regardless of hypsarrhythmia (HS) on EEG and neurodevelopmental delay, accounts for 10% of epileptic cases that begin prior to 36 months of age [1]. Incidence is estimated to be 2–3 per 10 000 live births, and the prevalence of IESS is approximately 0.015 cases per 1 000 people [2, 3]. The etiologies of IESS are largely heterogeneous and encompass almost all identifiable causes of epilepsy. In 2017, the International League Against Epilepsy (ILAE) classified the etiologies of epilepsy into six groups [4], which have implications for treatment options.