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Lennox-Gastaut syndrome (LGS) is a childhood-onset epilepsy associated with intractable seizures and variable but usually severe cognitive and behavioural impairments[1]. One of the most complex epilepsies to manage, up to 90% of patients fulfill diagnostic criteria for intellectual disability (ID), including a standardised intelligence quotient (IQ) below 70[2–6]. A minority of patients can display a cognitive profile within normal or near-normal limits[2], [3], [7], [8], but with slowed mental processing still leading to difficulties performing day-to-day activities[1].