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Drug-resistant epilepsy often requires intracranial monitoring to delineate the seizure onset zone (SOZ) prior to undergoing surgical treatment. The concept of epileptogenic zone, described by Rosenow and Lüders, refers to the cortex required for generation of the patient’s epileptic seizures and which should be resected to render the patient seizure free [1]. This region contains the SOZ, which is the actual cortical tissue observed to produce the patient’s typical seizures; however, the epileptogenic zone may extend beyond this.