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Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) with childhood-onset, typically before the age of 8 years and most commonly between the ages of 2 and 5 years [1,2]. LGS is characterized by the presence of (i) multiple seizure types, including tonic seizures, atypical absences and tonic or atonic drop attacks, and (ii) abnormal electroencephalogram (EEG) activity, consisting primarily of interictal slow-spike waves (SSW) and paroxysmal fast rhythms during non-REM sleep [3].