Altered dynamic functional connectivity of striatal-cortical circuits in Juvenile Myoclonic Epilepsy

Juvenile myoclonic epilepsy (JME) is one of the most common idiopathic generalized epilepsies (IGE), accounting for up to 10% of all epilepsies. It is characterized by the main features of myoclonus with generalized spike-and-wave (GSWDs) and polyspike-and-waves on EEG [1]. The seizures in JME often start and terminate through a sudden transition and the pathophysiology of JME remains unknown. In general, JME is considered involving wide brain networks including cortical and subcortical networks, especially the fronto-thalamic networks [2].