Focal thalamocortical circuit abnormalities in sleep related epilepsy caused by focal cortical dysplasia type II

As a common form of malformation of cortical development, focal cortical dysplasia (FCD) type II is one of the most common histopathological diagnoses of drug-resistant focal epilepsy in patients undergoing resective epilepsy surgery [1]. FCD type II frequently presents with sleep-related epilepsy (SRE) [2–5], defined as seizures occurring exclusively or predominantly during sleep [6,7]. The pathological substrate of FCD type II increases the risk of SRE in respect of other histopathological substrates, regardless of its location [2,5].

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