Circulating malondialdehyde level in patients with epilepsy: A meta-analysis

Oxidative stress is described as an imbalance in the production and clearance of reactive oxygen species and reactive nitrogen species [1]. Lipids are the most important biomolecules affected by many forms of oxidative stress. Lipid oxidation produces several secondary products, mainly aldehydes, which can intensify oxidative damage. Malondialdehyde (MDA) is the main product of peroxidation of polyunsaturated fatty acids and is also the most studied product [2]. Epilepsy is a neurological disorder that affects at least 50 million people worldwide, and oxidative stress may be a mechanism underlying the onset of epilepsy.

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