ABCG2, SCN1A and CYP3A5 genes polymorphism and drug-resistant epilepsy in children: A case-control study

Epilepsy is a common neurological disorder in children with an incidence rate between 41 and 187 per 100,000 persons globally (1, 2). Developing countries, particularly in rural areas have higher incidence rates (2). Although several antiseizure medicines (ASM) have been developed in recent decades, it is estimated that about 20% of patients fail to respond to standard therapies and continue to experience debilitating drug-resistant seizures (1, 3).

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