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SCN8A developmental and epileptic encephalopathy (SCN8A-DEE) is a rare and serious genetic epilepsy syndrome characterized by early-onset developmental delay and/or regression, cognitive impairment, and multiple intractable seizure types.[1-4] The SCN8A gene is highly expressed in the central nervous system and encodes the Nav1.6 voltage-gated sodium ion channel, which has a major role in regulating the excitatory neuronal networks in the brain.[1-3]