Epilepsy is one of the most common neurological diseases [1]. In about a third of all patients, seizure freedom is not achieved by anti-seizure medication (ASM) [2, 3]. These patients are referred to as “drug resistant”. Drug resistant epilepsy (DRE) in children is not clearly defined. In early infancy the definition is even more complicated and differs in many aspects from DRE in children and adolescents. Seizures in the neonatal period and first month of life are most frequently caused by acute brain injury, i.e., hypoxic-ischemic encephalopathy or intraventricular hemorrhage [4].
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