Laser Ablation for Corpus Callosotomy: Systematic Review and Pooled Analysis

The corpus callosotomy (CC) was first introduced by Van Wagenen and Herren in 1940 as a palliative procedure to control refractory seizures [1]. Their hypothesis was based on the idea that the corpus callosum as the connecting bridge for interhemispheric spread of epileptic activity. Hence, this procedure is typically used to treat atonic seizures (drop attacks), which are highly refractory, but is also used to prevent generalization of other seizure types and syndromes, especially, Lennox-Gastaut Syndrome (LGS) [2].

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