Six-month outcomes of the CODES randomised controlled trial of cognitive behavioural therapy for dissociative seizures: a secondary analysis

While psychological interventions are considered to be the treatment of choice for adults with dissociative seizures (DS), evidence for such treatments was limited prior to the ‘Cognitive behavioural therapy vs standardised medical care for adults with Dissociative non-Epileptic Seizures (CODES)’ Trial. The CODES trial set out to investigate the effectiveness of standardised medical care (SMC) alone versus DS-specific Cognitive Behavioural Therapy (CBT) plus SMC for adults with DS [1–3]. Before completion of the CODES trial only two pilot randomised controlled trials (RCTs) had been completed using different CBT approaches [4, 5] which suggested efficacy for CBT-based interventions.

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