Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis

Epilepsy is one of the most common neurological diseases with an apparent genetic predisposition, and the incidence rate in men is normally higher than that in women [1]. Moreover, several studies have reported that children have a higher incidence rate of epilepsy than adults [2–3]. During epileptogenesis, overexcitatory neurons in local lesions cause paroxysmal abnormal high-frequency discharges, and the discharges spread to the surrounding area, leading to abrupt, recrudescent and ephemeral brain dysfunction [4].

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