Depending on the suspected etiology of an epileptic seizure, a lumbar puncture for CSF analysis is recommended to exclude potentially treatable causes, such as intrathecal infections or autoimmune inflammation [1]. Routine diagnostics include analysis of cell count as well as protein and lactate levels [1,2]. Here, pathologically altered CSF parameters may indicate a specific etiology of the epileptic seizure, especially in infectious or autoimmune CNS disorders [1]. On the other hand, pathologic CSF findings, e.g., persistent intrathecal immunoglobulin synthesis or blood-CSF barrier dysfunction, may also indicate a competing or already resolved disease that is not directly related to epileptic seizures.
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