Antiseizure medication (ASM) therapy remains the main treatment of epilepsy at present, with 65%–85% of patients with epilepsy becoming seizure-free after receiving appropriate medication treatment[1]. Up to 88% of patients suffer from one or more ASM adverse effects, such as memory impairment and depressed mood[2], resulting in decreased quality of life. Consequently, ASM discontinuation may be considered in patients with epilepsy, whose seizures have been completely controlled for a prolonged remission period, typically two to five years without interictal epileptiform discharges (IEDs)[3,4].
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