Genetic-Cellular Epilepsy: Clues to Diagnosing Newborns with Neonatal Seizures

Seizures are the most frequent sign of neurological dysfunction in newborns. They occur in an estimated 2-3 per 1,000 term newborns and in 10-15 per 1,000 in preterms [1,2]. They are mostly due to acute brain injury such as hypoxic ischaemic encephalopathy (HIE), ischaemic or haemorrhagic stroke, metabolic disorders, or infection but are sometimes the first sign of neonatal-onset epilepsy due to pathogenic genetic mutations [3].

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