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Laminin alpha-2-related muscular dystrophy (LAMA2-RD), caused by mutations in the LAMA2 gene, covers a wide spectrum of clinical disorders [1] that are typically divided into two main phenotypic categories: merosin-​deficient congenital muscular dystrophy type 1A (MDC1A), which is one of the most frequent forms of congenital muscular dystrophy (CMD) [2,3], and the milder and later-onset limb-girdle muscular dystrophy (LGMD) R23 phenotype [4]. The LAMA2 gene, located on chromosome 6q22-q23, encodes for the alpha-2 heavy chain of laminin-211 (laminin alpha-2, also called merosin), a major component of the basal membrane, linked to the dystrophin-glycoprotein complex [3].