Glutathione-dependent peroxidases (GPxs) belong to a widespread family of proteins that has been discovered in almost all kingdoms of life [1,2]. GPxs have eight isoforms in mammals, and GPx1–4 in mice and humans and GPx6 in humans contain selenocysteine at their active sites and thus are categorized as selenoproteins [3,4]. Other GPxs are nonselenium glutathione peroxidases [5]. GSH-Px is a selenium-dependent enzyme that is expressed in the human brain and has an important role in the detoxification of reactive oxygen and reactive nitrogen species-related oxidative stress [6,7].
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