Patients with a first seizure or newly established epilepsy undergo routine diagnostics, mainly EEG and neuroimaging. First, these serve to clarify if a diagnosis of epilepsy can be established. Second, they aid in establishing epilepsy classification and etiology. However, test results may not be definite and clinical circumstances may demand additional laboratory tests including cerebrospinal fluid (CSF) analysis. This review aims at exploring the impact of seizures on CSF results and when CSF analysis is useful in (differential) diagnosis of seizures and epilepsy.
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