Recent advances in epilepsy research have revealed that the epileptic brain generates high frequency brain signals (HFBS, > 80 Hz), which can be detected invasively [1–5] and noninvasively [6–9]. Invasive recordings [1–5] have provided solid evidence that HFBS play an important role in epileptogenesis and epileptogenicity. The resection of the brain areas generating HFBS can predict favorable outcomes of epilepsy surgery [10–12]. Noninvasive technologies, such as magnetoencephalography (MEG) and scalp electroencephalography (EEG), have shown promising results for detection and localization of HFBS [6–9].
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