Blood concentration of levetiracetam after bolus administration in patients with status epilepticus

The treatment for patients with status epilepticus (SE) consists of the following steps: treating early-stage SE for more than 5 min; treating established-stage SE with benzodiazepines for 30 min or longer; and treating refractory-stage SE with antiepileptic drugs for 60 min or longer. The first-line drugs used in the first step are benzodiazepines, such as lorazepam or diazepam (DZP), which stop the seizure immediately. However, these drugs are considered effective for approximately 20 min and unsuitable for the second and third stages [1].

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