Epilepsy is a neurological disorder that affects nearly 50 million people worldwide, characterized by an enduring predisposition to generate unprovoked recurrent seizures [1]. About 30% of patients with epilepsy do not achieve complete seizure control, despite receiving adequate antiseizure drug (ASD) treatment [2,3]. It is known that more severe epilepsies are more difficult to control. Indeed, recurrent and high frequency severe seizures are hypothesized to facilitate the drug resistant phenotype in epilepsy [4,5] and status epilepticus [6,7].
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