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Epilepsy with febrile seizures plus (EFS+) is an entity featured by febrile seizures plus (FS+) or epilepsy following FS+, including FS+, generalized epilepsy and febrile seizures plus (GEFS+), partial epilepsy and febrile seizures plus (PEFS+), FS+ and other intractable epilepsy [1-4]. The severe Dravet syndrome (DS) also occurs in EFS+ spectrum [1,5-6]. Many previous studies revealed that EFS+ was related to genetic cause [2,6-8]. A feature of EFS+ is genetic heterogeneity, i.e., patients with the same mutation have different disease manifestations.