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Tuberous sclerosis complex (TSC) is an autosomal dominant disorder affecting multiple-organ systems, with all patients having loss-of-function mutations in either the TSC1 (encoding hamartin) or TSC2 (encoding tuberin) genes [1-3]. The incidence of patients with TSC is reported as 1 case per 6,000–10,000 live births [3, 4]. Approximately 80–90% of TSC patients are affected by epilepsy, which is the most common symptom in patients with TSC, and most of them have related symptoms in the first year after birth [5].