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Proton pump inhibitors (PPIs) is among the most commonly prescribed drugs worldwide, and is often the treatment of choice for gastric acid-related disorders. [1] The common adverse events of PPIs are diarrhea, headache, nausea, dizziness and generalized abdominal pain. [2,3] There were two prescription-event monitoring studies reporting an incidence of seizures or convulsions in PPI recipients. [4,5] The first study reported 17 convulsion events among 16,204 PPI users during a 12-month follow-up period, [4] and the other study reported one epilepsy event among 11,541 PPI users during a 6-month follow-up period.