Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms

Infantile spasms is a common developmental epileptic encephalopathy, characterised by epileptic spasms, in patients less than two years of age. Most patients show hypsarrhythmia on electroencephalography (EEG) and developmental delay [1–3]. The standard treatments for infantile spasms are adrenocorticotropic hormone (ACTH), vigabatrin (VGB), and prednisolone; their efficacies are 40–76%, 36–54%, and 39–70%, respectively [4–8]. In 2017, the International League Against Epilepsy proposed a new classification that incorporates aetiologies into the diagnosis [9].

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