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Intraoperative electrocorticography (ECoG) is widely used during epilepsy surgery. The removal of areas showing interictal epileptiform discharges, especially spikes, recorded in the preresection ECoG is associated with increased freedom from seizures [1,2]. However, there are still debates about the usefulness of intraoperative spikes for delineating epileptogenic areas [2–5]. One reason for this controversy is that intraoperative epileptic activity is strongly affected by the types and concentrations of anesthesia [6].