Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations

There exists a considerable body of literature on the increased risk of developing epileptic seizures as an adverse effect of antibiotic therapy. β-lactams and fluoroquinolones are most frequently associated with central nervous system toxicity and neurological side effects [1]. Although infrequent, other classes of antibiotics have also been reported to induce neurotoxicity or trigger epileptic seizures. Gamma-aminobutyric acid (GABA) receptor antagonism is a common mechanism shared by penicillins, cephalosporins, imipenem, and fluoroquinolones [2,3].

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