Effects of perampanel on secondary bilateral synchrony and behavioral problems in adolescents with epilepsy showing insufficient response with levetiracetam

A relationship has been observed between epilepsy and impairment of neuropsychological functioning in children. For focal epilepsies, the relationships between seizures and interictal epileptiform discharges are controversial, but some interictal epileptiform activities show subtle clinical manifestations. Interictal epileptiform discharges on the electroencephalogram (EEG) are regarded as a correlate of persistent pathological neuronal discharges [1]. Cognitive and behavioral problems are common in children with atypical seizure semiology and/or atypical EEG features [2,3].