Plant derived versus synthetic cannabidiol: wishes and commitment of epilepsy patients

Medical cannabis (MC) has been used in various medical conditions for centuries. Over the last decades, scientific research has revealed several mechanisms of action of cannabis and its compounds. Of more than 120 known cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD) have been most thoroughly investigated. For CBD, a non-psychoactive cannabinoid, anticonvulsant potential has been shown in different animal models [1] and Class 1 evidence was revealed in severe paediatric epilepsy syndromes (Lennox-Gastaut-Sydrome and Dravet-Syndrome) [2,3].

0