Epileptic encephalopathies (EEs) are severe brain disorders of early age characterized by: (1) aggressive paroxysmal activity on electroencephalography (EEG), (2) seizures that are usually multiform and drug-resistant, (3) cognitive, behavioral and motor deteriorations that may be persistent, and (4) sometimes early death. [1] The concept of “epileptic encephalopathies” refers to the fact that the epileptic activity itself causes progressive cognitive and behavioral deterioration or regression [1,2].
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