In people with epilepsy, depressive disorders are frequent comorbidities, constituting a challenge to complex treatment strategies. Administering antidepressants to such individuals is controversial because multiple studies and case reports indicate pro-convulsant effects for tricyclic antidepressants (TCAs) and in some cases for serotonin selective reuptake inhibitors (SSRIs) as well.[1] For this reason, TCAs are contraindicated in depressed people with epilepsy while SSRIs are often used in this population even though their possible pro-convulsant effects are variable.[2] We report the case of a woman with intractable epilepsy whose seizures entirely stopped after receiving sertraline, a widely used SSRI.
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