As part of the brain’s immune system, the cerebral glymphatic system plays an important role in waste clearance from the brain [1,2]. Cerebral perivascular Virchow-Robin spaces (VRS) are functional networks of the cerebral glymphatic system surrounding the perforating arterioles and venules in the brain parenchyma [1,2]. They are always located between the endothelial basement membrane and the basement membrane of the glia limitans [3]. Additionally, the VRS are responsible for immune surveillance and drainage of soluble proteins and metabolic waste products from the brain, within the overarching glymphatic system [4,5].
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