The Exploration of the Spectrum of Motor Manifestations of Anti-LGI1 Encephalitis beyond FBDS

Anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis is a type of autoimmune encephalitis with an antibody targeting neuronal surface antigens [1]. LGI1, which is primarily expressed in the hippocampus and temporal cortex, serves as a component of voltage-gated potassium channel (VGKC) complexes by acting as the ligand for two epilepsy-related proteins, ADAM22 and ADAM23 [2,3], thus epileptic seizures are common symptoms [4–9]. Other paroxysmal events, especially motor events, such as faciobrachial dystonic seizures (FBDS), bizarre behaviors, sleep disorders and so on, were also likely to be the initial symptoms or the main reasons for the visit [4,5,8–10].