Mesial temporal lobe epilepsy (mTLE) is major contributor to the group of drug resistant epilepsies and is one of the leading indications for epilepsy surgery, the most common pathology being hippocampal sclerosis (HS) [1]. There is a significant group of patients with mTLE that do not have any lesions on MRI, called “non-lesional” or “MRI-negative [2]. These patients pose a challenge for treatment in terms of difficult presurgical work-up, frequently warranting intracranial EEG recordings. There is evidence that non-lesional patients fare worse in surgical outcomes in general as compared to lesional ones [3].
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