Mitochondrial myoclonic epilepsy requires specific treatment

With interest we read the review article by Orsini et al. about myoclonic epilepsy in Unverricht-Lundborg disease, Lafora disease, neuronal ceroid lipofuscinoses, myoclonus epilepsy with ragged-red fibers (MERRF), and sialidoses type 1 and 2 [1]. The authors recommend valproic acid (VPA) as first choice for myoclonic epilepsy irrespective of the underlying cause followed by lamotrigine (LTG), primidone (PRM), phenobarbital (PB), and levetiracetam (LEV) [1]. Other anti-seizure drugs (ASD) that can be considered for myoclonic epilepsy include topiramate (TPM), zonisamide (ZNS), ethosuximide (ESX), felbamate (FLB), benzodiazepines (BZD), and perampanel (PER) [1].

0