HUMAN NEOCORTICAL INTERICTAL EPILEPTIFORM DISCHARGES ARE INITIATED BY A LOW-VOLTAGE NEGATIVE POLARITY WAVE

Epilepsy is a disease that affects the electrical activity of the brain. Epileptic seizures are paroxysms of electrical discharges that disrupt the brain’s ability to process information. In between seizures, a brain with epilepsy generates isolated electrical discharges known as interictal epileptiform discharges (IEDs) (Stern and Engel, 2013). IED identification corroborates a diagnosis of epilepsy and enables classification of the underlying type of epilepsy (Stern and Engel, 2013). In some cases, IED waveforms correlate with underlying pathology (Noachtar et al., 2008; Tassi et al., 2012).

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