Efficacy of Statin Therapy in Post-Stroke Seizure Prophylaxis: Clues from an Observational Study of Routine Secondary Prevention Treatment

Stroke is a common cause of epilepsy in the elderly population. The abnormal neuronal discharges of post-stroke seizures (PSS) can cause damage to neurons and worsen the outcome of stroke. Numerous studies have focused on the clinical epidemiology of PSS; and the reported incidence varies from 2% to 20%, depending on the study population, stroke subtype, and the seizure onset time after the stroke [1–4]. Patients with early-onset seizures (ES) have a high risk of disability and mortality [1,5], whereas those with late-onset seizures (LS) and post-stroke epilepsy (PSE) tend to end up with poorer outcomes [6].