In 1628, Sir William Harvey, the famous English physician, stated that “For every affection of the mind that is attended with either pain or pleasure, hope or fear, is the cause of an agitation whose influence extends to the heart” [1]. In this article, we explore the interaction of brain and heart in patients with epilepsy, focusing on new insights into possible pathways from epilepsy, catecholaminergic toxicity, subtle cardiac changes and sudden death. Translational lessons from cardiac models of disease and ultra-structural lesions are used to support these considerations.
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