Status epilepticus (SE) is one of the most common neurological emergencies in children, with an incidence of 17-23/100,000 per year [1–4]. Pediatric SE is associated with a short-term mortality of 0-3% [1,4–8] which is as high as 20-40% [9] in refractory SE (rSE). One of the most disabling features of epilepsy and SE is the apparently unpredictable timing of seizure occurrence [10]. However, seizures, and presumably SE, follow day and multiday rhythms [10–13].
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