Daytime sleepiness in patients with epilepsy (PWE) has been intensively studied, though it remains highly controversial which clinical variable has the greatest relationship. One of the earliest studies of daytime sleepiness in PWE conducted by Hoeppner et al. [1] emphasized the role of epileptic activity in enhancing daytime sleepiness. While some ensuing reports supported that view [2], others did not and instead of epilepsy-related influence proposed other factors. Along with psychiatric co-morbidity and sleep disorders such as restless leg syndrome, antiepileptic drugs (AEDs) have also been reported to potentially cause excessive daytime sleepiness (EDS) in PWE [2].
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