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A variety of psychiatric symptoms are encountered in patients with epilepsy (PWE), which are now widely recognized to have effects more important than seizure frequency and may also be a more powerful determinant of quality of life in that population [1]. There is a large variety of factors associated with psychiatric symptoms in PWE. For effective treatment, it is important to first disentangle the amalgamated complex and focus attention on more potent determinants, while some antiepileptic drugs (AEDs) must be considered as causative factors.