There are many comorbidities in people with epilepsy (PWE), with depression being the most frequent comorbidity. The lifetime prevalence for depression is around 10% in the general population  but is estimated at 30% in PWE . A bidirectional relationship between depression and epilepsy was described more than 2000 years ago . Depression may lower the seizure threshold . Many recent epidemiological studies have found that the presence of primary depressive disorder was associated with a three to seven fold higher risk of developing epilepsy [5,6].