Diagnostic Usefulness of Arterial Spin Labeling in MR Negative Children with New Onset Seizures

Epilepsy is the most frequent and chronic neurologic disorder and carries risks of significant morbidity and mortality. Despite the introduction of new antiepileptic drugs, one-third of patients suffer from drug resistant epilepsy [1]. In these patients, especially those with focal epilepsy, surgical treatment aiming to remove the seizure focus may represent the only available option for becoming seizure free. If the magnetic resonance (MR) result does not reveal structural abnormalities, identifying the epileptogenic zone is more challenging in these patients than in those with structural abnormalities [2,3].