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Stereotactic neurosurgery was initially developed in the second half of the XXth century as a solution to the high morbidity of invasive open surgery [1]. Historically, in epilepsy surgery stereotactic procedures were mainly used to localize the seizure onset zones through the recording of intracranial-EEG by stereoelectroencephalography (SEEG) [2]. More recently, following the growing accuracy of the delineation of the seizure onset zone and epileptic networks, the surgical management of drug-resistant epileptic patients faced new challenges [3–5].