Chewing induced reflex seizures („eating epilepsy“) and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: review of literature and report of 8 cases

Epilepsy is a common disorder in children, with an incidence of 0.05-0,1% in developed countries (1) and a heterogeneous etiology. Within the etiology there is a high genetic contribution ranging from benign epilepsy syndromes to epileptic encephalopathies in children. New technologies such as next generation sequencing (NGS), allowing mutational screening of many more genes in parallel, led to major progress in the understanding of epilepsy syndromes, especially in children (2–4).