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The reported risk of developing post-encephalitic/encephalopathic epilepsy (PEE) in patients who had acute encephalitis/encephalopathy was 6.8% and 16.4% [1,2]. Previous studies have shown that PEE accounts for 5.5% and 10.4% of patients with intractable epilepsy [3,4]. PEE is recognized as drug-resistant epilepsy, and patients with PEE are often affected by adverse effects related to poly-pharmaceutical therapy. We previously reported that sleepiness as an adverse effect of antiepileptic drugs might be causally related to prolonged blood-brain barrier (BBB) dysfunction in patients with PEE [5].