Ictal hypoxemia: a systematic review and meta-analysis

Ictal respiratory changes (IRCs) have been recognized for more than 100 years [1] and are commonly seen in generalized and focal seizures [2]. IRCs include a range of alterations, from central and obstructive apnea, tachypnoea, bradypnea to hypoventilation and hypoxemia [3]. IRCs, and most importantly respiratory depression such as hypoxemia, hypercapnia and central apnea, have attracted attention in several clinical contexts, including SUDEP [4–6] and seizure detection in the epilepsy monitoring unit [7–9].